Apex Dermatology Institute


    Psoriasis is a chronic relapsing immune mediated skin inflammatory disease. It is more common in Caucasians, the disease prevalence in Chinese is around 0.47% from study. It is regarded as a systemic disease as it also affects patients' joints and metabolic syndrome. Patients may have itchy scaly erythematous plaques especially over scalp, extensor surfaces over joints or even develop into erythroderma in severe cases.

    Diagnosis is often established by clinical features. Treatment choices mainly depend on disease severity and patients comorbidity. Topical steroids and vitamin D analogue are usually suitable for mild psoriasis. Patients with more severe cases may be given oral systemic medications including immunosuppresants. Biologics, including Tumour necrosis factor alpha antagonists (anti-TNF) or various interleukin antagonists are breakthrough treatment options in recent years which provide satisfactory response with less systemic side effects.

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    Medical Therapy for Psoriasis

      For patients with moderate or severe psoriasis, using biologics can help to clear your skin. Biologics are made from proteins, they can effectively target the immune response that leads to the skin proliferation of psoriasis. Below are some biologics available at our clinic:



      1. Guselkumab (Tremfya) is a biologic that selectively blocks interleukin-23 (IL-23), one of the key proteins thought to be responsible for the symptoms of plaque psoriasis. It is used to treat adults with moderate to severe plaque psoriasis.


      2. Ixekizumab (Taltz) is a biologic that selectively blocks interleukin-17A (IL-17A). It is used to treat adults with moderate to severe plaque psoriasis.


      3. Secukinumab (Cosentyx) belongs to a class of drugs known as monoclonal antibodies. It works by blocking a certain natural protein in your body (Interleukin-17A) that may cause inflammation and swelling. IL-17A is a naturally occuring cytokine that is involved in normal inflammatory and immune responses. Secukinumab inhibits the release of proinflammatory cytokines and chemokines.

      It is used to treat adults with moderate to severe plague psoriasis that involves large areas or many areas of the body, as well as active psoriatic arthritis and ankylosing spondylitis.

      This medication is given by injection under your skin (subcutaneous injection) in the upper arms, thighs, or abdomen area. The recommended dose of secukinumab for plaque psoriasis is 300 mg by subcutaneous injection at weeks 0, 1, 2, 3, and 4. Majority of clinical trial participants achieved clear or almost clear skin at 12 weeks.

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